Mammalian Peripheral Circadian Oscillators Are Temperature Compensated
نویسندگان
چکیده
منابع مشابه
Peripheral circadian oscillators in mammals.
Although circadian rhythms in mammalian physiology and behavior are dependent upon a biological clock in the suprachiasmatic nuclei (SCN) of the hypothalamus, the molecular mechanism of this clock is in fact cell autonomous and conserved in nearly all cells of the body. Thus, the SCN serves in part as a "master clock," synchronizing "slave" clocks in peripheral tissues, and in part directly orc...
متن کاملPeripheral circadian oscillators require CLOCK
In mammals, the circadian system is hierarchical — a brain pacemaker located within the suprachiasmatic nucleus (SCN) is responsible for regulating locomotor activity rhythms and for synchronizing peripheral oscillators [1,2]. Recent genetic evidence in mice indicates that the bHLH transcription factors CLOCK and NPAS2 have partially redundant functions within the SCN [3,4]. To further examine ...
متن کاملRhythms of Mammalian Body Temperature Can Sustain Peripheral Circadian Clocks
BACKGROUND Low-amplitude temperature oscillations can entrain the phase of circadian rhythms in several unicellular and multicellular organisms, including Neurospora and Drosophila. Because mammalian body temperature is subject to circadian variations of 1 degrees C-4 degrees C, we wished to determine whether these temperature cycles could serve as a Zeitgeber for circadian gene expression in p...
متن کاملPhysical Unclonable Functions based on Temperature Compensated Ring Oscillators
Physical unclonable functions (PUFs) are promising hardware security primitives suitable for low-cost cryptographic applications. Ring oscillator (RO) PUF is a well-received silicon PUF solution due to its ease of implementation and entropy evaluation. However, the responses of RO-PUFs are susceptible to environmental changes, in particular, to temperature variations. Additionally, a convention...
متن کاملTemperature-compensated circadian clock in the pineal of Anolis.
The pineal organ of the lizard Anolis carolinensis can be maintained for up to 10 days in superfused organ culture. During this time it synthesizes and releases melatonin into the medium flowing slowly over it. Collection of timed aliquots of medium and subsequent analysis for melatonin by radioimmunoassay reveal circadian rhythms of melatonin output by the isolated pineal. These rhythms persis...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Biological Rhythms
سال: 2008
ISSN: 0748-7304,1552-4531
DOI: 10.1177/0748730407311855